Sex differences in brain atrophy in multiple sclerosis

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[Sex-related differences in atrophy and lesion load in multiple sclerosis patients].

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We used cross-sectional tensor-based morphometry to visualize reduced volume in the whole brains of pediatric patients with multiple sclerosis, relative to healthy controls. As a marker of local volume difference, we used the Jacobian determinant of the deformation field that maps each subject to a standard space. To properly assess abnormal differences in volume in this age group, it is necess...

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UNLABELLED The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categor...

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Sex differences in resting-state functional connectivity in multiple sclerosis.

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M ultiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS) characterized by a relapsing-remitting course in the majority of the patients. In the last two decades, an increasing number of approved drugs for MS showed efficacy on clinical relapses and magnetic resonance imaging (MRI) lesions related to inflammatory activity in the CNS. Alth...

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ژورنال

عنوان ژورنال: Biology of Sex Differences

سال: 2020

ISSN: 2042-6410

DOI: 10.1186/s13293-020-00326-3